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KMID : 0644119990120020001
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Journal of Oriental Gynecology
1999 Volume.12 No. 2 p.1 ~ p.40
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Effects of A Constituent Herbs of Samul-tang on Paeoniflorin
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朴賢淑/Park, Hyun Sook
李京燮/宋炳基/Lee, Kyung Sub/Song, Byoung Key
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Abstract
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In order to investigate interactive effects of each herb in Samul-tang, Angelicae gigantis Radix, Cnidii Rhizoma, Rehmanniae Radix Preparat, and Paeoniae Radix, test liquids, which have one of them, three ones of them, and all of them, were used to examine the difference in extractive rates of each test solutions, absorptive rates at small intestine and metabolic rates by liver homogenate. And we examined the effects on activities of intestinal bateria.
The results were summerized as follows
1. In the examination of extractive rate of paeoniflorin, it was shown lowest in Paeoniae Radix + Rehmanniae Radix Preparat solution.
2. In the examination of absorptive rate at mice´s small intestine, it was relatively increased by Paeoniae Radix + Rehmanniae Radix Preparat solution and Samul-tang solution and relatively decreased by Paeoniae Radix + Cnidii Rhizoma solution.
3. In the examination of paeoniflorin metabolic rates by liver homogenate, it was relatively increased by Paeoniae Radix + Angelicae gigantis Radix + Rehmanniae Radix Preparat solution.
4. It was acknowledged that paeonimetabolin Ⅰ, Ⅱ were made when paeoniflorin was cultured with intestinal flora, and Bacteriodes sp. PM strain had the best metabolic activity.
5. Paeonimetabolin Ⅰ and Ⅱ were made when paeoniflorin was cultured with Bacteriodes sp. PM strain and β-glucosidase but other metabolite was not made.
6. In the examination of metabolic rates by intestinal flora and Bacteriodes sp. PM strain, it was severely decreased by Paeoniae Radix + Cnidii Rhizoma solution and Paeoniae Radix + Rehmanniae Radix Preparat + Cnidii Rhizoma solution.
7. In vitro, β-glucosidase activity was activated by each paeoniflorin, Paeoniae Radix, Rehmanniae Radix Preparat, and Cnidii Rhizoma solution concentration dependantly and severely inhibited Paeoniae Radix + Rehmanniae Radix Preparat + Cnidii Rhizoma solution and Samul-tang solution.
8. In vitro, α-rharnnosidase activity was inhibited concentration -dependantly by each single herbal solution.
9. In vitro, tryptophanase activity was activated only by Cnidii Rhizoma solution and inhibited by other test solutions.
10. In vivo, .β-glucosidase activity was severely activated by Paeoniae Radix, Angelicae gigantis Radix, Cnidii Rhizoma solution and severely inhibited by Rehmanniae Radix Preparat solution and Samul-tang solution.
11. In vivo, α-rhamnosidase activity was activated by paeoniflorin, Cnidii Rhizoma, Paeoniae Radix + Angelicae gigantis Radix and Paeoniae Radix + Angelicae gigantis Radix + Rehmanniae Radix Preparat solution.
12. In vivo, tryptophanase activity was activated every test solutions except Cnidii Rhizoma and Paeoniae Radix + Rehmanniae Radix Preparat + Cnidii Rhizoma solution and especially inhibited by Samul-tang solution.
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